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Hilde Mangold (20 October 1898 – 4 September 1924) (née Proescholdt) was a German Embryology who was best known for her 1923 dissertation which was the foundation for her mentor, Hans Spemann's, 1935 Nobel Prize in Physiology or Medicine for the discovery of the embryonic primitive knot,Mangold, Hilde (Proescholdt) by Marilyn Bailey Ogilvie and Joy Dorothy Harvey in The Biographical Dictionary of Women in Science. "one of the very few doctoral theses in biology that have directly resulted in the awarding of a Nobel Prize". Developmental Biology. 10th ed. by Scott F. Gilbert. The general effect she demonstrated is known as Embryogenesis, that is, the capacity of some cells to direct the developmental trajectory of other cells, one of the first steps towards cloning.. See Box 1: Explanation of the Spemann-Mangold experiment Induction remains a fundamental concept and area of ongoing research in the field.
This lecture inspired her to pursue her education in this field. After Frankfurt, she attended the Zoological Institute in Freiburg. It was here that she met and married her husband, , who was Spemann's chief assistant (and, incidentally, a supporter of the Nazi Party). Under Spemann's direction, she completed her 1923 dissertation, entitled “Über Induktion von Embryonalanlagen durch Implantation artfremder Organisatoren”, or “Induction of Embryonic Primordia by Implantation of Organizers from a Different Species.”
After earning her PhD in zoology, Hilde moved with her husband and infant son, Christian, to Berlin. Shortly after the move, Hilde died from severe burns as a result of a gas heater explosion in her Berlin home. She never lived to see the publication of her thesis results. Her son died in World War II.Hilde Proescholdt Mangold by Veronica Reardon Mondrinos in Women in the Biological Sciences, page 304.
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